Viewed in the reduction of medical expenses and the guardian’s burden, the development of polyvalent vaccine would be required, which can induce immunity for several pathogens once. We try to develop recombinant polyvalent vaccines based on the current varicella vaccine. The current varicella vaccine has been shown to have high efficacy and safety, and have an advantage for the insertion of foreign genes. Therefore, the vaccine is thought to be a recombinant vaccine vector.